Trace the pathway out loud, both directions.
Enzymes, regulation, and what breaks when a step is missing.
You can draw glycolysis and cannot say what happens when a step fails.
What Vera actually is
A phone call with someone who is not there. You say the thing out loud, they answer the way a real person would, and you get to do it again — as many times as it takes, with nobody listening.
15 minutes free · no card needed
15 minutes free · no card needed
Not practising doesn’t save you anything.
The ticket, the evening, the weeks of applying — all of it is spent before anyone says a word. The practice is the only cheap part, and the only part that changes how the rest goes.
15 minutes free · no card needed
What she'll actually ask
She asks these the way a real person would, then follows up on whatever you say.
- Trace this pathway and name the rate-limiting step.
- This enzyme is missing. What accumulates and what is depleted?
- How is that step regulated, and by what?
- What would the patient look like?
- Now trace it backwards.
More about this one
Biochemistry is tested through disruption — a missing enzyme, an accumulated intermediate, a regulatory step that fails. Memorizing a pathway diagram does not prepare you for that, because the diagram never shows what goes wrong. Verbal drilling forces you to trace consequences. Vera walks pathways with you and keeps asking what accumulates, what is depleted, and what the patient looks like.
What she listens for
- biochemistry pathways
- glycolysis
- rate-limiting step
- enzyme deficiency
- metabolic regulation
- accumulated intermediates
- inborn errors of metabolism
- pathway tracing
“I could draw every pathway perfectly and had no idea what a deficiency actually did. That is the entire exam.”
Related practice
Common questions
Can I do pathways without writing?
Yes, and it is harder in a useful way. Tracing aloud exposes the steps you were relying on the diagram for.
Which pathways?
Name them in your prompt — glycolysis, TCA, urea cycle, beta oxidation, and so on.
Good for Step 1?
Yes, the deficiency-and-consequence framing is exactly how Step 1 tests biochemistry.
What if I am bad at it?
Everyone is, on the first one. That is the entire reason it happens here and not there.
What if I do not know what to say?
She asks the first question and follows up on whatever you answer. You never start from a blank page.
What if it is awkward?
It is, for about twenty seconds. Then it is a conversation, and nobody heard the twenty seconds.
Ready to try it?
Your first 15 minutes are free. No card required.